A survey of error-correction methods for next-generation sequencing

Recount: expectation maximization based error correction tool for next generation sequencing data.

Next generation sequencing technologies enable rapid, large-scale production of sequence data sets. Unfortunately these technologies also have a non-neglible sequencing error rate, which biases their outputs by introducing false reads and reducing the quantity of the real reads. Although methods developed for SAGE data can reduce these false counts to a considerable degree, until now they have ...

An Empirical Evaluation of Error Correction Methods and Tools for Next Generation Sequencing Data

Next Generation Sequencing (NGS) technologies produce massive amount of low cost data that is very much useful in genomic study and research. However, data produced by NGS is affected by different errors such as substitutions, deletions or insertion. It is essential to differentiate between true biological variants and alterations occurred due to errors for accurate downstream analysis. Many ty...

Reptile: representative tiling for short read error correction

MOTIVATION Error correction is critical to the success of next-generation sequencing applications, such as resequencing and de novo genome sequencing. It is especially important for high-throughput short-read sequencing, where reads are much shorter and more abundant, and errors more frequent than in traditional Sanger sequencing. Processing massive numbers of short reads with existing error co...

Recount: Expectation Maximization Based Error Correction Tool for next Generation Sequencing Data

Karect: accurate correction of substitution, insertion and deletion errors for next-generation sequencing data

MOTIVATION Next-generation sequencing generates large amounts of data affected by errors in the form of substitutions, insertions or deletions of bases. Error correction based on the high-coverage information, typically improves de novo assembly. Most existing tools can correct substitution errors only; some support insertions and deletions, but accuracy in many cases is low. RESULTS We prese...